REDRESS
RElated haplo-DonoR haematopoietic stEm cell transplantation for adults with Severe Sickle cell disease
View DetailsSponsor
King's College Hospital NHS Foundation Trust
Description
This study is run by a multi-disciplinary team of doctors, nurses, scientists, statisticians, managers and administrators. The purpose of the REDRESS trial is to determine whether stem cell transplant using haplo-identical related donors is safe, effective, and cost worthy in treating adults with sickle cell disorder compared with the standard of…
Site name
Multisite
Site PI
Chief Investigator: Dr V. Potter
Start date
23/02/2023
End date
30/06/2027
Contact links
https://www.redresstrial.co.uk=https://www.redresstrial.co.uk redress@kcl.ac.uk
BioResources
View DetailsSponsor
NHIR
Description
This study aims to help with the development of more affordable DNA based tests for the diagnose of rare diseases and the discovery of genes causing rare disease. This requires for the volunteers to provide a small blood sample.
Site name
University Hospitals Bristol and Weston NHS Foundation Trust
Site PI
Dr S Lugthart
Start date
2018
End date
Ongoing
Contact links
Monica.lourenco@uhbw.nhs.uk
Rudy (Rare and Undiagnosed Diseases Study)
View DetailsSponsor
NIHR
Description
Rare and Undiagnosed diseases Study (RUDY) Using validated questionnaires and other information such as diagnostic history, clinical events, and treatments to gather information on rare disorders. Paediatric Study. The objective of the study is to gather information describing in detail the different types of rare diseases and what it is like…
Site name
Multisite
Site PI
Multisite
Start date
2018
End date
01-06-2023
Contact links
South West HCC, University Hospitals Bristol and Weston NHS Foundation Trust Site PI: Dr S Lugthart Site contact: Monica.lourenco@uhbw.nhs.uk North Central London & East Anglia - UCLH Site Contact: uclh.info.redcellnetworkhcc@nhs.net
NIHR Bioresource CCTU
View DetailsSponsor
NIHR
Description
Adult Thalassaemia Study. Transfusion dependent Thalassaemia & Non-Transfusion dependent Thalassaemia: NIHR Bioresource CCTU. NIHR BioResource – Rare Diseases study project (Haemoglobinopathies)
Site name
Red Cell Network
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
NIHR Mental Health Bioresource
View DetailsSponsor
Sponsor Data Pending
Description
NIHR Mental Health Bioresource - The Genetic Links to Anxiety and Depression (GLAD).
Site name
Whittington Health NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
ENERGIZE-T
View DetailsSponsor
AGIOS
Description
Adult Thalassaemia study. (AGIOS 018) CCTU – Phase 3, Double-blind, Randomized, Placebo-Controlled Study Evaluating the Efficacy and Safety of Mitapivat in Subjects with Alpha- or Beta-Thalassaemia
Site name
Site name Pending
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
Crosswalk-a
View DetailsSponsor
Sponsor Data Pending
Description
CROSSWALK-a: A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD).
Site name
Whittington Health NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
TAPS2
View DetailsSponsor
Sponsor Data Pending
Description
Transfusions Antenatally in Pregnant women with Sickle Cell Disease for improving maternal and infant outcomes.
Site name
Whittington Health NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
GBT-440-038
View DetailsSponsor
Sponsor Data Pending
Description
Paediatric Study. GBT 440-038- An Open-Label Extension Study of Voxelotor administered orally to paediatric participants with Sickle Cell Disorder who have participated in Voxelotor Clinical Trials.
Site name
UCLH
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
CSL889 Haemopexin CRF
View DetailsSponsor
Sponsor Name Pending
Description
Non-Transfusion Sickle Cell Disease: CSL889 haemopexin CRF - Safety and tolerability of CSL889 in Sickle Cell Disease: A Phase 1, Multi-Centre, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CSL889 in Adult Patients with Stable Sickle Cell Disease.
Site name
UCLH
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
GLADIOLUS (FT-4202)
View DetailsSponsor
Sponsor Data Pending
Description
Transfusion dependent Sickle Cell Disease: GLADIOLUS (FT-4202) CCTU - Phase 2 Open-Label Study to Evaluate Safety and Clinical Activity of FT-4202 in Patients with Thalassaemia or Sickle Cell Disease.
Site name
Site name Pending
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
Hibiscus Etavopivat PK Activator Study
View DetailsSponsor
Sponsor Data Pending
Description
Description Pending
Site name
Imperial College Healthcare NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
Gene Editing Vertex 141 Study
View DetailsSponsor
Sponsor Data Pending
Description
Description Pending
Site name
Imperial College Healthcare NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
PNH Pegcetacoplan Study
View DetailsSponsor
Sponsor Data Pending
Description
Description Pending
Site name
Imperial College Healthcare NHS Trust
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
NIHR BioResource- Rare Disease Arm
View DetailsSponsor
Sponsor Data Pending
Description
Rare Diseases Arm:- Sickle Cell Disorder and Thalassemia.
Site name
UCLH
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
The Molecular Investigation of Unexplained Anaemias and Relaed Congenital Anaemias
View DetailsSponsor
Sponsor Data Pending
Description
Description Pending
Site name
UCLH
Site PI
Site PI Pending
Start date
Start Date Pending
End date
End Date Pending
Contact links
uclh.info.redcellnetworkhcc@nhs.net
